Myotonic Dystrophy type 1 Astrocytes Acetylcholinesterase deficiency Autophagy RNA splicing Transgenic mouse model Centronuclear myopathy DM1 CTG repeats CRISPRi CTG repeat instability Acute coronary syndrome Glucocorticoids Mice Neuron KNOCKOUT MICE CTG repeat contractions Muscular dystrophy Gene editing Myotonic Dystrophy Cell model Motoneuron Cytoskeleton Myotonic dystrophy GSK3␤ MBNL Male Lc3 Desmin Myostatin RNA biology Myelin Cell penetrating peptide Dystrophie Myotonique Trinucleotide repeat expansion Dynamin 2 Intermediate filament Gene Therapy Quantitative microdialysis Glucocorticoid-receptor Brain dysfunction Fibrosis Glutamate Exercice Cell culture model Myotonic dystrophy type 1 Acetylcholinesterase knockout mouse Dystrophin Heart DMPK Maximal force Thérapie génique Exercise Brain Mouse model Dilated cardiomyopathy PacBio In vivo Glial cells Therapy PCR Long read sequencing DMSXL mice Duchenne muscular dystrophy Central nervous system Genotype phenotype correlation Hypoxia Dystrophie myotonique Astrocyte Skeletal muscle Transcriptomics Diaphragm GABA BIOLOGIE MOLECULAIRE Myotonic Dystrophy Type 1 RNA interference Trinucleotide Repeat Expansion Aging CMS Antisense oligonucleotide Oligodendrocytes Myotonic dystrophy mouse models Cardiac muscle Alternative splicing Antisense oligonucleotides Muscle Knockout ACETYLCHOLINESTERASE CRISPR/Cas9 Expression Oligodendrocyte CONGENITAL MYATHENIC SYNDROME Animals ARN Humans AAV Mouse models Transgenic mouse Heart failure Gene therapy