Hybrid simulation architecture gathering in a single framework and consistent time scales both the numerical integration of the continuous model of a bio-mechanical system (bones, joints and muscles) and a model of the hardware and software control architecture, including control tasks, communication protocols and real-time schedulers. Simulation run in real-time when possible, and otherwise consistent time scales are generated. The framework is intended to seamlessly evolve from purely software models to hardware-in-the-loop simulation.